2. Signaling Pathways
  3. PROTAC
  4. E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

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E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

E3 Ligase Ligand-Linker Conjugates Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-138856A
    Thalidomide-NH-amido-PEG3-C2-NH2 hydrochloride 2983036-99-1
    Thalidomide-NH-amido-PEG3-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-NH-amido-PEG3-C2-NH2 hydrochloride
  • HY-139546
    Thalidomide-5-propargyne-NH2 hydrochloride 2490402-62-3
    Thalidomide-5-propargyne-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-propargyne-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
    Thalidomide-5-propargyne-NH2 hydrochloride
  • HY-157596
    E3 ligase Ligand-Linker Conjugate 40
    E3 ligase Ligand-Linker Conjugate 40 is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. E3 ligase Ligand-Linker Conjugate 40 can be used as a key intermediate for the synthesis of complete PROTAC molecules.
    E3 ligase Ligand-Linker Conjugate 40
  • HY-139999
    LCL-PEG3-N3 3033849-90-7
    LCL-PEG3-N3 is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER(dec), degrading the estrogen receptor. LCL-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    LCL-PEG3-N3
  • HY-159550
    (S,R,S)-AHPC-CO-cyclohexene-Bpin
    SMARCA2/4-ligand-Linker Conjugate-5 is an E3 ligase ligand-linker conjugate.
    (S,R,S)-AHPC-CO-cyclohexene-Bpin
  • HY-168040
    Thalidomide-O-C5-piperidine-NH-Boc
    Thalidomide-O-C5-piperidine-NH-Boc is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-O-C5-piperidine-NH-Boc can be used to synthesize PROTAC PIN1 degrader-1 (HY-168037).
    Thalidomide-O-C5-piperidine-NH-Boc
  • HY-155264
    Pomalidomide-5-C8-NH2 hydrochloride 2863635-03-2
    Pomalidomide-5-C8-NH2 hydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C8-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
    Pomalidomide-5-C8-NH2 hydrochloride
  • HY-157598
    E3 ligase Ligand-Linker Conjugate 46
    E3 ligase Ligand-Linker Conjugate 46 is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. E3 ligase Ligand-Linker Conjugate 46 can be used as a key intermediate for the synthesis of complete PROTAC molecules.
    E3 ligase Ligand-Linker Conjugate 46
  • HY-W957364
    Pomalidomide-C2-Br 2940940-74-7
    Pomalidomide-C2-Br is an E3 Ligase Ligand (HY-14658) and linker (HY-W007731) conjugate. Pomalidomide-C2-Br can be used to synthesize PROTAC AR Degrader-8 (HY-170329).
    Pomalidomide-C2-Br
  • HY-148406
    (S,R,S)-AHPC-C10-NHBoc 2412055-13-9 98.32%
    (S,R,S)-AHPC-C10-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC (HY-125845) based VHL ligand and a linker used for BET-Targeted PROTAC.
    (S,R,S)-AHPC-C10-NHBoc
  • HY-163214
    (S)-PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid
    (S)-PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.
    (S)-PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid
  • HY-163215
    (S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc
    (S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
    (S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc
  • HY-162611
    8-Hydroxyoctanoic acid-thalidomide 2399454-65-8
    8-Hydroxyoctanoic acid-thalidomide is an E3 Ligase Ligand-Linker Conjugate. 8-Hydroxyoctanoic acid-thalidomide can be used to synthesize Lw13 (HY-162589).
    8-Hydroxyoctanoic acid-thalidomide
  • HY-128815
    cIAP1 Ligand-Linker Conjugates 14 1351169-40-8
    cIAP1 Ligand-Linker Conjugates 14 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 14 can be used to design SNIPERs.
    cIAP1 Ligand-Linker Conjugates 14
  • HY-130965B
    Thalidomide-PEG3-NH2 hydrochloride 2983036-20-8 98.02%
    Thalidomide-PEG3-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-PEG3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
    Thalidomide-PEG3-NH2 hydrochloride
  • HY-153337A
    Pomalidomide-C11-NH2 hydrochloride 2722611-55-2
    Pomalidomide-C11-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
    Pomalidomide-C11-NH2 hydrochloride
  • HY-163937
    (S,R,S)-AHPC-O-CF3 -CO-cyclohexane
    (S,R,S)-AHPC-O-CF3 -CO-cyclohexane is an E3 Ligase Ligand-Linker Conjugate. (S,R,S)-AHPC-O-CF3 -CO-cyclohexane can be used to synthesize PROTAC SMARCA2/4-degrader-20 (HY-163873).
    (S,R,S)-AHPC-O-CF3 -CO-cyclohexane
  • HY-139335
    VH 101 phenol-alkylC4-amine dihydrochloride 2564467-03-2
    VH 101 phenol-alkylC4-amine dihydrochloride is a von-Hippel-Lindau protein ligand (VHL), and incorporates an E3 ligase ligand plus an alkylC4 linker. VH 101 phenol-alkylC4-amine dihydrochloride can be used for PROTAC research extracted from patent WO2022051326A1.
    VH 101 phenol-alkylC4-amine dihydrochloride
  • HY-W584515
    Thalidomide-NH-(CH2)3-NH-Boc 2093386-36-6
    Thalidomide-NH-(CH2)3-NH-Boc is a Boc-modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-(CH2)3-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-(CH2)3-NH-Boc is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules targeting 11β-substituted estradiol.
    Thalidomide-NH-(CH2)3-NH-Boc
  • HY-159679
    E3 Ligase Ligand-linker Conjugate 116 2409844-90-0
    E3 Ligase Ligand-linker Conjugate 116 is an E3 ubiquitinase ligand + linker conjugate (E3 Ligase Ligand-Linker Conjugates). E3 Ligase Ligand-linker Conjugate 116 can be used to synthesize PROTAC SMARCA2/4-degrader-28 (HY-162835).
    E3 Ligase Ligand-linker Conjugate 116
Cat. No. Product Name / Synonyms Application Reactivity
E3 Ligase Ligand-Linker Conjugates Isoform Comparison

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